ANTIBIOTIC RESISTANCE PATTERNS OF ESCHERICHIA COLI AND KLEBSIELLA SPP. FROM PUS SAMPLES IN A TERTIARY CARE HOSPITAL IN NORTH,RAJASTHAN

Bhawani Shankar Verma, Rachna khatri, Dr. Farkhanda, Abhishek Sharma

Abstract


BACKGROUND:-The skin and soft infections (SSTIs) is one of the most common complications after trauma, burn, and surgical procedures resulting pus, which is a collection of dead WBCs, necrotic tissues, and cellular debris. Mostly Pyogenic infection caused by Enterobacteriaceae member such as E.coli and Klebsiella spp. The emergence of resistance necessitates periodic studies to determine their antibiogram. The objective of this study is to characterize the pyogenic bacteria and to determine their antibiotic susceptibilities.

MATERIALS AND METHODS- Pus samples from National institute of medical science (NIMS) Hospital was collected and processed as per CLSI guidelines.

 RESULTS- Analysis of 325 pus samples showed 73.81% culture positivity. The most common organism was E.coli (33.87%) followed by Klebsiella Spp. The most resistance drug in Gram negative bacteria were resistance to in E.coli and Klebsiella spp. The most Resistant drug in Escherichia coli was Ampicillin (83.3%) closely followed by Ciprofloxacin (79.2%), Cefotaxime (79.2%). and Klebsiella spp. was Levofloxacin (85.7%), Ceftriaxone (82.1%), Ciprofloxacin (82.1%) and 100% resistance is Ampicillin because it is intrinsic resistance for Klebsiella spp.

CONCLUSION-Rapid emergence of multidrug-resistant bacteria poses a serious threat to public health globally due to the limited treatment options however the changing trends of antimicrobial susceptibility in bacterial isolates from pus can serve as a vital tool for clinicians to start empirical treatment of patients at the earliest.


Keywords


ESCHERICHIA COLI AND KLEBSIELLA SPP.

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